4 & 8 together bring disaster.

On May 22(4) the eighth(8) deadliest tornado in U.S. history
devastated Joplin,Missouri.The tornado first touched down at 5:35(4) Central time.

That time adds up to 4.

It occurred on Saturday which is ruled by 8.

The full Universal Date 22/5/2011 also adds upto 4.

Joplin is the 4th largest metropolitan area in the
state of Missouri.
On the city website it states that the population within a 40-mile radius is 400,000.

The city of Joplin lies at the crossroads of Interstate Highway 44(8) and U.S. Highway
71(8).

Both 44 and 71 add up to the number 8.